PROSIT aims at identifying, designing and testing innovative solutions for improving vineyard resilience to drought by harnessing the natural resources of endophyte microbial communities. PROSIT will unravel the role of microbiome-grapevine association in the response of the plant to drought stress, and harness the potential of natural biodiversity of microbiome arisen in regions with different climatic conditions to define microbe consortia to be used in sustainable viticultural practices in future adverse environmental conditions. More closely, our research aims to understand to which extent different Vitis vinifera varieties adaptation to water deficit is influenced by the microbiome, and whether such a beneficial microbiome is transmissible to other varieties.